In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. Sulfonylurea agents or insulin may cause hypoglycemia. This medication should not be used if you have certain medical conditions. United States and its territories. Indications, uses and warnings on Drugs.
Symptoms of low blood sugar include anxiety; behavior change similar to being drunk; blurred vision; cold sweats; confusion; cool, pale skin; difficulty in thinking; drowsiness; excessive hunger; fast heartbeat; headache continuing; nausea; nervousness; nightmares; restless sleep; shakiness; slurred speech; or unusual tiredness or weakness. What happens if I overdose Precose? Also, the fewer variables in your program, the easier your successes and failures are to track. Your pharmacist can provide more information about acarbose.
Ask your health care provider any questions you may have about how to use acarbose. Lab tests may be performed while you use acarbose. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments. Macrovascular Outcomes: There have been no clinical studies establishing conclusive evidence of macrovascular risk reduction with Acarbose Tablets or any other anti-diabetic drug.
Take at the start with first bite of each main meal; patients should be adhering to a diabetic diet to minimize GI side effects. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Hypoglycemia: Because of their mechanism of action, Acarbose Tablets when administered alone should not cause hypoglycemia in the fasted or postprandial state. Sulfonylurea agents or insulin may cause hypoglycemia. Because Acarbose Tablets given in combination with a sulfonylurea or insulin will cause a further lowering of blood glucose, it may increase the potential for hypoglycemia. Hypoglycemia does not occur in patients receiving metformin alone under usual circumstances of use, and no increased incidence of hypoglycemia was observed in patients when Acarbose Tablets were added to metformin therapy. Oral glucose dextrose whose absorption is not inhibited by Acarbose Tablets, should be used instead of sucrose cane sugar in the treatment of mild to moderate hypoglycemia. Sucrose, whose hydrolysis to glucose and fructose is inhibited by Acarbose Tablets, is unsuitable for the rapid correction of hypoglycemia.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Acarbose treatment resulted in a significant increase in the incidence of renal tumors adenomas and adenocarcinomas and benign Leydig cell tumors. This study was repeated with a similar outcome. Further studies were performed to separate direct carcinogenic effects of Acarbose from indirect effects resulting from the carbohydrate malnutrition induced by the large doses of Acarbose employed in the studies. In one study using Sprague-Dawley rats, Acarbose was mixed with feed but carbohydrate deprivation was prevented by the addition of glucose to the diet. In a 26-month study of Sprague-Dawley rats, Acarbose was administered by daily postprandial gavage so as to avoid the pharmacologic effects of the drug. In both of these studies, the increased incidence of renal tumors found in the original studies did not occur. Acarbose was also given in food and by postprandial gavage in two separate studies in Wistar rats. No increased incidence of renal tumors was found in either of these Wistar rat studies. In two feeding studies of hamsters, with and without glucose supplementation, there was also no evidence of carcinogenicity. Acarbose Tablets should be taken three times daily at the start with the first bite of each main meal. Acarbose Tablets should be started at a low dose, with gradual dose escalation as described below, both to reduce gastrointestinal side effects and to permit identification of the minimum dose required for adequate glycemic control of the patient. If the prescribed diet is not observed, the intestinal side effects may be intensified. If strongly distressing symptoms develop in spite of adherence to the diabetic diet prescribed, the doctor must be consulted and the dose temporarily or permanently reduced. Other Abnormal Laboratory Findings: Small reductions in hematocrit occurred more often in Acarbose Tablets-treated patients than in placebo-treated patients but were not associated with reductions in hemoglobin. Low serum calcium and low plasma vitamin B 6 levels were associated with Acarbose Tablets therapy but are thought to be either spurious or of no clinical significance. Many people find that taking steps like these greatly reduces symptoms of dumping syndrome. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take acarbose by mouth at the start with the first bite of each main meal. Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. As with any medical decision, be sure to work with your doctor to ensure the best choices are made for your condition. Check your blood sugar carefully during times of stress, travel, illness, surgery or medical emergency, vigorous exercise, or if you drink alcohol or skip meals. These things can affect your glucose levels and your dose needs may also change. Do not change your medication dose or schedule without your doctor's advice. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. Acarbose. In rabbits, reduced maternal body weight gain, probably the result of the pharmacodynamic activity of high doses of Acarbose in the intestines, may have been responsible for a slight increase in the number of embryonic losses.
Symptoms of high blood sugar hyperglycemia include thirst, increased urination, confusion, drowsiness, flushing, rapid breathing, and fruity breath odor. If these symptoms occur, tell your doctor right away. Your dosage may need to be increased or you may need other drugs. If swallowing is difficult, then the capsule may be opened and the contents mixed in a small amount of liquid or soft food that does not need to be chewed such as room-temperature applesauce. Do not mix the contents of the capsule with alkaline food or liquid such as milk, ice cream, tea. Diarrhea, gas, upset stomach, constipation, or stomach pain may occur in the first few weeks of treatment as your body adjusts to this medication but usually improve with time. Follow your prescribed diet to help lessen these side effects. If any of these effects persist or worsen, tell your doctor or pharmacist promptly. If you miss a dose, take the next dose with your next meal or snack as directed. This contains to help break down and digest fats, starch, and proteins in food. Water pulled out of the bloodstream moves into the small intestine. The fraction of Acarbose that is absorbed as intact drug is almost completely excreted by the kidneys. When Acarbose was given intravenously, 89% of the dose was recovered in the urine as active drug within 48 hours. In contrast, less than 2% of an oral dose was recovered in the urine as active that is, parent compound and active metabolite drug. This is consistent with the low bioavailability of the parent drug. The plasma elimination half-life of Acarbose activity is approximately 2 hours in healthy volunteers. In a one-year safety study, during which patients kept diaries of gastrointestinal symptoms, abdominal pain and diarrhea tended to return to pretreatment levels over time, and the frequency and intensity of flatulence tended to abate with time. The increased gastrointestinal tract symptoms in patients treated with Acarbose Tablets are a manifestation of the mechanism of action of Acarbose Tablets and are related to the presence of undigested carbohydrate in the lower GI tract. You should take the prescribed dose with the FIRST BITE of each main meal. A small dose will be started and your health care provider will gradually increase it as needed. Your health care provider may want you to combine Precose with another type of diabetes pill. Since Precose works differently than the other diabetes pills, it will not interfere with their action. Combined with these pills, Precose may further improve your control. Take acarbose with the first bite of a main meal, unless your doctor tells you otherwise. Acarbose Tablets were statistically significantly different from placebo at all doses with respect to effect on one-hour postprandial plasma glucose. A1c, complete blood counts should be performed periodically to check for side effects and monitor your response to therapy. Check your blood or urine sugar levels regularly as directed by your doctor or pharmacist. iressa
If you have not already been diagnosed with the dumping syndrome, and you have confusion, dizziness, rapid heartbeat, or fainting, get immediate medical help. Call 911 right away. What should I avoid while taking acarbose Precose? Lack of interaction between thioctic acid, glibenclamide and acarbose. Acarbose Tablets are available as 25 mg, 50 mg and 100 mg for oral use. The inactive ingredients are starch, microcrystalline cellulose, magnesium stearate, and colloidal silicon dioxide. Hyperglycemia high blood sugar may occur if you do not take enough or skip a dose of your antidiabetic medicine, overeat or do not follow your meal plan, have a fever or infection, or do not exercise as much as usual. primperan suppository price primperan
Initial Dosage: The recommended starting dosage of Acarbose Tablets is 25 mg given orally three times daily at the start with the first bite of each main meal. However, some patients may benefit from more gradual dose titration to minimize gastrointestinal side effects. Acarbose is used to treat type 2 diabetes. Acarbose is sometimes used in combination with insulin or other diabetes medications you take by mouth. Take this medication by with meals and snacks as directed by your doctor. Swallow the capsule whole. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. It is a group of symptoms that may result from having part of your removed or from other surgery involving the stomach. The symptoms range from mild to severe and often subside with time. Although you may find dumping syndrome alarming at first, it is not life threatening. You can control it by making changes in what and how you eat. This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. Do NOT take more than the recommended dose without checking with your doctor. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Symptoms of high blood sugar include blurred vision; drowsiness; dry mouth; flushed, dry skin; fruit-like breath odor; increased urination; ketones in urine; loss of appetite; stomachache, nausea, or vomiting; tiredness; troubled breathing rapid and deep; unconsciousness; or unusual thirst. Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional. It may be harder to control your blood sugar during times of stress, such as fever, infection, injury, or surgery. Talk with your doctor about how to control your blood sugar if any of these occur. Do not change the dose of your medicine without checking with your doctor. Where can I get more information? The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.
Know the signs of low blood sugar hypoglycemia and how to recognize them: headache, hunger, weakness, sweating, tremors, irritability, or trouble concentrating. Inform your doctor if your condition persists or worsens. Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. If you are currently using any of these medications listed above, tell your doctor or pharmacist before starting acarbose. Combine proteins or fats along with fruits or starches. For example, combine fruit with cottage cheese. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. Digestive Tract: Gastrointestinal symptoms are the most common reactions to Acarbose Tablets. How should I take acarbose? Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. For acarbose to work properly it must be taken at the beginning of each main meal. sorf.info benicar
Intestinal adsorbents for example, charcoal and digestive enzyme preparations containing carbohydrate-splitting enzymes for example, amylase, pancreatin may reduce the effect of Acarbose Tablets and should not be taken concomitantly. FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. Cut food into very small pieces. Chew well before swallowing. If no further reduction in postprandial glucose or HbA1c is observed with titration to 100 mg three times a day, consider lowering the dose. If you miss a dose of Glycomet, take as soon as possible. Do not double doses. cheapest atopex purchase pharmacy australia
If you miss a dose of acarbose, skip the missed dose and go back to your regular dosing schedule. Do not double doses. An early dumping phase may happen about 30 to 60 minutes after you eat. Precose therapy or placebo, titrating to a maximum dose of 100 mg three times daily. To evaluate the long-term efficacy of precose in improving glycemic control in subjects with NIDDM, a one-year, multicenter, randomized, double-blind, placebo-controlled study was conducted. The study involved 354 subjects with NIDDM. Clinical studies demonstrated a strong association between hyperglycemia and an increased risk of microvascular tissue damage. Trials involving Precose established that hemoglobin levels are a more significant predictor of the onset or progression of retinopathy in NIDDM diabetic patients than blood glucose concentration. Precose significantly reduced hemoglobin levels in NIDDM subjects maintained on dietary therapy alone. The magnitude of the treatment effect steadily increased during active treatment; diabetic retinopathy was reduced by approximately 30%. You may be more likely to have hyperglycemia high blood sugar if you are taking acarbose with other drugs that raise blood sugar. Check with your pharmacist about how to dispose of unused medicine. In case of overdose, do not eat or drink anything containing carbohydrates for the next 4 to 6 hours. What should I avoid while taking acarbose? Acarbose Tablets are contraindicated in patients with known hypersensitivity to the drug. Acarbose Tablets are contraindicated in patients with diabetic ketoacidosis or cirrhosis. Acarbose Tablets are also contraindicated in patients with inflammatory bowel disease, colonic ulceration, partial intestinal obstruction or in patients predisposed to intestinal obstruction. In addition, Acarbose Tablets are contraindicated in patients who have chronic intestinal diseases associated with marked disorders of digestion or absorption and in patients who have conditions that may deteriorate as a result of increased gas formation in the intestine. Abteilung Klinische Pharmakologie, Universitat Gottingen, Gottingen, Germany.
If any of these effects persist or worsen, tell your doctor or promptly. Sorry I couldn't provide a more sound scientific basis, but there are foods around that are not expensive, not genetically engineered, and provided very stable carbohydrate management without having to use a myriad of advanced concoctions. Acarbose has no inhibitory activity against lactase and consequently would not be expected to induce lactose intolerance. You may experience blurred vision, dizziness, or drowsiness due to extremely low or high blood sugar levels. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Limit alcoholic beverages because they can increase the risk of developing low blood sugar. Therefore, treatment of these patients with Acarbose Tablets is not recommended. Acarbose is only part of a complete program of treatment that may also include diet, exercise, weight control, foot care, eye care, dental care, and testing your blood sugar. Follow your diet, medication, and exercise routines very closely. Changing any of these factors can affect your blood sugar levels. Acarbose does not cause low blood sugar hypoglycemia. Your doctor may want you to stop taking acarbose for a short time if you become ill, have a fever or infection, or if you have surgery or a medical emergency. In a study of 6 healthy men, less than 2% of an oral dose of Acarbose was absorbed as active drug, while approximately 35% of total radioactivity from a 14C-labeled oral dose was absorbed. An average of 51% of an oral dose was excreted in the feces as unabsorbed drug-related radioactivity within 96 hours of ingestion. Because Acarbose acts locally within the gastrointestinal tract, this low systemic bioavailability of parent compound is therapeutically desired. Following oral dosing of healthy volunteers with 14C-labeled Acarbose, peak plasma concentrations of radioactivity were attained 14-24 hours after dosing, while peak plasma concentrations of active drug were attained at approximately 1 hour. The delayed absorption of Acarbose-related radioactivity reflects the absorption of metabolites that may be formed by either intestinal bacteria or intestinal enzymatic hydrolysis. During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor. Your doctor may substitute insulin for this drug during your pregnancy. Follow all instructions carefully. Acarbose is to be used only by the patient for whom it is prescribed. Do not share it with other people. buy proventil online reviews
Eight carcinogenicity studies were conducted with Acarbose. Six studies were performed in rats two strains, Sprague-Dawley and Wistar and two studies were performed in hamsters. Acarbose is only part of a complete treatment program that may also include diet, exercise, weight control, regular blood sugar testing, and special medical care. Follow your doctor's instructions very closely. Symptoms of an early phase happen because food is rapidly "dumping" into the small intestine. Swallow the food or liquid right away, making sure not to chew the medication. Drink a glass of water or juice after swallowing the food to make sure all the medication is swallowed. Do not save the medication mixture for later. Do not take more capsules in a day than prescribed by your doctor. Your condition will not improve any faster, and your risk of side effects will increase. Your blood sugar will need to be checked often, and you may need other blood tests at your doctor's office. If your symptoms do not improve or if they become worse, check with your doctor. cabergoline
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Severe allergic reactions rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; bloody stools; severe or persistent diarrhea or constipation; severe stomach pain; unusual bleeding or bruising. The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables. What is the most important information I should know about acarbose Precose? What happens if I miss a dose Precose? tacrolimus tablets brand names
Do not use table sugar also called cane sugar or sucrose to relieve these symptoms because acarbose delays its breakdown. Carry glucose tablets or gel with you to treat low blood sugar. If you are in a situation where you don't have these reliable forms of glucose, eat some honey or drink a glass of orange juice sources of another sugar, fructose to quickly raise your blood sugar level. Tell your doctor about the reaction right away. To help prevent low blood sugar, eat meals on a regular schedule, and do not skip meals. Check with your doctor or pharmacist to find out what you should do if you miss a meal.
If you take acarbose with insulin or other diabetes medications, your blood sugar could get too low. Low blood sugar hypoglycemia can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. How should I take acarbose Precose? Adding the a-glucosidase inhibitor, Bayer Corp. Keep all medicines away from children and pets. AIMS: Thioctic acid TA glibenclamide and acarbose are widely used to either alone or concomitantly treat patients suffering from noninsulin-dependent diabetes NIDDM. This study systematically investigated drug-drug interactions between TA and glibenclamide and TA and acarbose. METHODS: Fourteen male and 10 female healthy volunteers participated a randomized, open three period cross over trial treatments A-C followed by a fourth period treatment D. A baseline profile for plasma insulin and glucose concentrations, variables which served as pharmacodynamic measures, was assessed before entering the trial. iressa purchase now online shop
Use acarbose as directed by your doctor. Check the label on the medicine for exact dosing instructions. FDA pregnancy category B. Acarbose is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment. In the 59 cases where follow-up was recorded, hepatic abnormalities improved or resolved upon discontinuation of Acarbose Tablets in 55 and were unchanged in two. Cases of fulminant hepatitis with fatal outcome have been reported; the relationship to Acarbose is unclear. albendazole